Radoje (Rade) Drmanac, Ph.D.

Chief Scientific Officer
Complete Genomics, Inc.
Mountain View, California, U.S.A.

Biographical information

Dr. Radoje (Rade) Drmanac, chief scientific officer and co-founder of Complete Genomics since 2006 and senior vice president of BGI since 2013, is a research scientist and inventor in the field of human genome sequencing including techniques such as DNA sequencing-by-hybridization (SBH), genomic micro- and nanoarrays, combinatorial probe ligation, and long fragment read (LFR) process for accurate whole genome sequencing and haplotyping from 10 human cells. In 1994, he co-founded Hyseq (later Nuvelo) where, as chief scientific officer, he led the effort to discover and patent thousands of genes which formed the basis of Nuvelo’s drug development pipeline. Prior to Hyseq, Rade was a group leader at Argonne National Labs from 1991 to 1994 as part of the Department of Energy’s Human Genome Project. He completed his postdoctoral studies in 1990 in Hans Lehrach’s group at the Imperial Cancer Research Fund in London. He earned his Ph.D. in molecular biology for the conception and pioneering development of SBH technology from Belgrade University, where he also received B.S. and M.S. degrees in molecular biology.

Selected publications

  1. B. Peters, B. Kermani, O. Alferov, M. Agarwal, M. McElwain, N. Gulbahce, D. Hayden, Y. Tang, R. Zhang, R. Tearle, B. Crain, R. Prates, A. Berkeley, S. Munne, R. Drmanac, Detection and Phasing of Single Base De Novo Mutationsin Biopsies from Human In Vitro Fertilized Embryos by Advanced Whole-genome Sequencing. Genome Research, 11 Feb 2015.
  2. B. Peters, J. Liu, R. Drmanac, Co-barcoded sequence reads from long DNA fragments: A cost-effective solution for “Perfect Genome” sequencing. Frontiers in Genetics, 18 Dec 2014.
  3. R. Drmanac, B. Peters, G. Church, C. Reid, X. Xun, Accurate Whole Genome Sequencing as the Ultimate Genetic Test, Clinical Chemistry, 5 Dec 2014.
  4. Y. Lin, M. Boone, Meuris, I. Lemmens, N. Van Roy, A. Soete, J. Reumers, M. Moisse, S. Plaisance, R. Drmanac, J. Chen, F. Speleman, D. Lambrechts, Y. Van de Peer, J. Tavernier, and N. Callewaert, Genome Dynamics of the Human Embryonic Kidney 293 Lineage in Response to Cell Biology Manipulations. Nature Communications 5, Article number: 4767, 03 Sep 2014.
  5. C. Mizzi, B. Peters, C. Mitropoulou, K. Mitropoulos, T. Katsila, M. Agarwal, R. van Schaik, R Drmanac, J. Borg, and G. Patrinos, Personalized Pharmacogenomics Profiling Using Whole-genome Sequencing. Pharmacogenomics. 2014 Jun;15(9):1223-34.
  6. C. Schaaf, M González-Garay, F. Xia, L. Potocki, K. Gripp, B. Zhang, B. Peters, M. McElwain, R. Drmanac, A. Beaudet, C. Caskey, and Y. Yang, Truncating Mutations of MAGEL2 Cause Prader-Willi Phenotypes and Autism. Nature Genetics 45, 1405–1408, 29 Sep 2013.
  7. B. Peters, B. Kermani, A. Sparks, O. Alferov, P. Hong, A. Alexeev, Y. Jiang, F. Dahl, Y. Tang, J. Haas, K. Robasky, A. Wait Zaranek, J. Lee, M. Price Ball, J. Peterson, H. Perazich, G. Yeung, J. Liu, L. Chen, M. Kennemer, K. Pothuraju, K. Konvicka, M. Tsoupko-Sitnikov, K. Pant, J. Ebert, G. Nilsen, J. Baccash, A. Halpern, G. Church, R Drmanac, Accurate Whole-genome Sequencing and Haplotyping from 10 to 20 Human Cells, Nature 487, 190-95, 12 July 2012.
  8. R. Drmanac, The Ultimate Genetic Test, Science, 1 June 2012: Vol. 336 no. 6085 pp.1110-1112 (DOI: 10.1126/science.1221037). Summary. Reprint. Full Text.
  9. P. Carnevali, J. Baccash, A. Halpern, I. Nazarenko, G. Nilsen, K. Pant, J. Ebert, A. Brownley, M. Morenzoni, V. Karpinchyk, B. Martin, D. Ballinger, and R. Drmanac, Computational Techniques for Human Genome Resequencing Using Mated Gapped Reads, Journal of Computational Biology. March 2012, 19(3): 279-292. doi:10.1089/cmb.2011.0201.
  10. W. Funk, I. Labat, J. Sampathkumar, P. Gourraud, J. Oksenberg, E. Rosler, D. Steiger, N. Sheibani, S. Caillier, B. Stache-Crain, J. Johnson, L. Meisner, M. Lacher, K. Chapman, M. Park, K. Shin, R. Drmanac, M. West, Evaluating the Genomic and Sequence Integrity of Human ES Cell Lines; Comparison to Normal Genomes, Stem Cell Research, Volume 8, Issue 2, March 2012, Pages 154–164.
  11. R. Drmanac, The Advent of Personal Genome Sequencing, Genetics in Medicine, 2011.
  12. R. Drmanac, et al., Human Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays, Science, 5 November 2009 (10.1126/science.1181498). Abstract
  13. R. Drmanac, et al., Third-Generation Complete Human Genome Sequencing of Multiple Individuals, poster presented at the 59th Annual Meeting of the American Society of Human Genetics, Honolulu, HI, 23 October 2009. View poster>>
  14. A. Schirinazi, S. Drmanac, B. Dallapiccola, S. Huang, K. Scott, A. DeLuca, D. Swanson, R. Drmanac, S. Surrey, P. Fortina, Combinatorial Sequencing-by-Hybridization: Analysis of the NF1 Gene, Genetic Testing 10(1): 8-17, 2006.
  15. S. Cowie, S. Drmanac, D. Swanson, K. Delgrosso, S. Huang, D. du Sart, R. Drmanac, S. Surrey, P. Fortina, Identification of APC gene mutations in colorectal cancer using universal microarray-based combinatorial sequencing-by-hybridization. Hum Mutat. 24(3):261-71, 2004.
  16. R. Drmanac, et al. Sequencing by Hybridization (SBH): Advantages, Achievements, and Opportunities, Advances in Biochemical Engineering/Biotechnology: Chip Technology Editor: J. Hoheisel, 76:75-98, 2002.
  17. R. Drmanac, S. Drmanac, cDNA screening by array hybridization, Methods in Enzymology, 303:165-178, May 1999.
  18. S. Drmanac, D. Kita, I. Labat, B. Hauser, J. Burczak, R. Drmanac, Accurate sequencing by hybridization for DNA diagnostics and individual genomics, Nature Biotechnology, 16, 54-58, 1998.
  19. S. Drmanac, N.A. Stavropoulos, I. Labat, J. Vonau, B. Hauser, M.B. Soares, R. Drmanac, Gene-Representing cDNA Clusters Defined by Hybridization of 57,419 Clones from Infant Brain Libraries with Short Oligonucleotide Probes, Genomics, 37, 29-40, 1996.
  20. R. Drmanac, S. Drmanac, J. Jarvis, I. Labat, Sequencing by hybridization. In: Automated DNA Sequencing and Analysis Techniques (M. Adams, C. Fields, J. C. Venter, eds.), pp 29-36, Academic Press Limited, London, 1994.
  21. R. Drmanac, S. Drmanac, Z. Strezoska, I. Labat, T. Paunesku, M. Zeremski, J. Snoddy, W.K. Funkhouser, B. Koop, L. Hood, R. Crkvenjakov, DNA Sequence Determination by hybridization: a strategy for efficient large-scale sequencing. Science, 260, 1649-1652, 1993.
  22. Z. Strezoska, T. Paunesku, I. Labat, D. Radosavljevic, R. Drmanac, R. Crkvenjakov, A Hundred Base Pairs of Beta1-Interferon Gene Sequence Determined by Oligo Hybridizations. Proc. Natl. Acad. Sci. USA, 88, 10089, 1991.
  23. H. Lehrach, R. Drmanac, J. Hoheisel, Z. Larin, G. Lennon, D. Nizetic, T. Monaco, G. Zehetner, A. Poustkal, Hybridization Fingerprinting in Genome Mapping and Sequencing. Genome Analysis 1, Genetic and Physical Mapping, Cold Spring Harbor Laboratory Press, 39-81, 1991.
  24. R. Drmanac, I. Labat, R. Crkvenjakov, An Algorithm for the DNA Sequence Generation from a k-tuple Word Contents of the Minimal Number of Random Fragments. J. Biomol. Struct. Dyn., 5, 1085, 1991.
  25. R. Drmanac, R. Crkvenjakov, Prospects for a Miniaturized, Simplified and Frugal Human Genome Project, Scientia Yugoslavica 161(1-2), 97-107, 1990.
  26. R. Drmanac, Z. Strezoska, I. Labat, S. Drmanac, R. Crkvenjakov, Reliable Hybridization of Oligonucleotides as Short as 6 Nucleotides in Length. DNA and Cell Biol. (formerly "DNA"), 9, 527, 1990.
  27. R. Drmanac, I. Labat, I. Brukner, R. Crkvenjakov, Sequencing of Megabase plus DNA by Hybridization: Theory of the Method, Genomics, 4, 114, 1989.

Research Interests

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